Sticky nightshade (Solanum sisymbriifolium) is a summer active perennial weed posing serious threats to agricultural and natural ecosystems in Australia. Major infestations are present in NSW, with scattered infestations in ACT, Qld, Vic and SA. Within NSW, most infestations occur in the Central Tablelands, Western Sydney and Wollongong areas. Isolated plants were also reported in the Central West, South East, Hunter, North Coast, North West and Riverina regions. Sticky nightshade infests agricultural and horticultural crops, native grassland, fence lines, roadsides, riparian zones, rocky slopes and natural reserves. Heavy infestations affect crop/pasture productivity, reduce stock carrying capacity, and degrade biodiversity in natural ecosystems. The sharp prickles on the leaves and stems can injure people, pets, livestock and native animals. The weed is highly invasive and it can grow to more than 2 m high if left uncontrolled. It can be spread by berries/seeds, but also by root and stem fragments. The weed is very difficult to control. Regrowth is common after herbicide applications, frosts or control by mechanical means. There are limited options to effectively manage sticky nightshade, with aminocyclopyrachlor 240 g/L being the only registered herbicide. PERMIT 12942 (expires 30/08/2025) allows the use of picloram based products. Our multi-year and multi-site study aimed to identify effective chemistries and optimum timing for controlling sticky nightshade through screening a broad range of residual and post-emergent herbicides at different growth stages of the weed. Several effective candidates have been identified, which includes aminocyclopyrachlor, picloram products, imazapyr, Amitrole T and tebuthiuron. Two applications of some selected post-emergent herbicides between spring and autumn were also highly effective. The integration of these alternative chemistries with other non-chemical control options will be discussed.